Risperidone v CBT for OCD

risperidoneRisperidone and CBT for OCD

An important paper was published by Blair Simpson et al (2013) in the USA last week   http://dx.doi.org/10.1001/jamapsychiatry.2013.1932

The paper describes a controlled trial in which 100 people with OCD who had received a SSRI medication for at least 3 months and had moderate OCD symptoms were randomized to receive either (A) risperidone (an anti-psychotic) or (B) Pill placebo or (C) Cognitive behaviour therapy over 17 sessions. At the end of 8 weeks, the CBT was significantly superior to either risperidone or placebo. There was no difference between those who received risperidone or placebo.

In the UK, the NICE guidelines (2005) recommend that CBT is used as the treatment for people with OCD for mild to moderate OCD. A SSRI is recommended if a person does not want CBT or something to be added to CBT if a person is not making sufficient progress.  Other options include more intensive CBT. Drugs like risperidone are not recommended unless a person with OCD is severe and has received at least 2 trials of SSRIs and of CBT.

Anti-psychyotics were recommended by NICE because other published trials showed some minor benefit in OCD. Anti-psychotics like risperidone may still be effective in severe treatment refractory OCD  as the population in this trial had never received CBT and had had just one trial of a SSRI – however we don’t really know who they may benefit.

Whilst discussing anti-psychotics, it’s worth mentioning a recent paper by Diniz et al (2011) http://dx.doi.org/10.1097/JCP.0b013e3182367aee who reported another trial in which they randomly allocated OCD patients who failed to respond to a SSRI (fluoxetine) by adding either clomipramine (an older drug used in OCD) or quietapine (an anti-psychotic like risperidone). Those who received clomipramine with  to fluoxetine did better than those who received quietapine. Others have reported using high doses of a SSRI (e.g fluoxetine 80mg or more) to be helpful in people with OCD who were resistant to lower doses.

Thus for all these reasons I don’t personally like to recommend anti-psychotics even in severe treatment refractory OCD because the possible benefits are minimal and side-effects can be a significant problem. They are of course justified in schizophrenia but they need to be closely monitored in terms of the possible side effects. Thus, in my view, anti-psychotics are only ever justified when a person with OCD is severely agitated and if they are used in the short term.

At present the Highly Specialized Service for severe treatment refractory OCD (which is funded centrally rather locally) requires a person to be in the severe range of symptoms and have failed at least two sets of CBT, two trials of SSRIs or clomipramine and one trial of “augmentation” of a SSRI. Augmentation could be (1) an anti-psychotic (like risperidone), which as I have described has weak  evidence (2) combining SSRI with clomipramine or (3) high dose of the SSRI. If I was a patient, and had failed CBT and SSRI (each twice) then I would want more intensive CBT. If I wanted to try another medication then I think I would opt for either the combination of a SSRI with clomipramine or a high dose SSRI.

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